Loss of cell identity drives human aging: Two new papers
erictopol.substack.com45 points by bookofjoe a day ago
45 points by bookofjoe a day ago
So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.
Do we currently have the ability to do targeted methylation or de methylation at sites in cells?
Good news! Research shows that hope reduces stress! [0]
[0]: https://www.forbes.com/sites/tracybrower/2024/09/15/how-bein...
What about Xanax or medication. Hypothetically ignoring the ill effects of the drugs themselves will chemical stress relief have the same anti-aging benefits?
If you believe that HRV is inversely correlated with stress then Xanax has the opposite of your intended effect.
I suspect that epigenetic aging is adaptive; a deliberately programmed sequence wherein genes more likely to contribute to age-related mortality are shut down progressively. This being in response to random genetic damage accumulating at a predictable rate.
What we think of as aging then becomes primarily the epigenetic response to the problem of DNA damage, much like the symptoms of a virus are mostly the result of the immune response rather than the virus’s direct effects.