Electromechanical reshaping, an alternative to laser eye surgery

medicalxpress.com

295 points by Gaishan 3 days ago


Topfi - 3 days ago

Just for context and as this article only mentions LASIK and not other options such as (Trans-)PRK and SMILE, the majority of negative side effects one experiences post LASIK are not linked to the ablation/"carving" of the cornea, as they call it, but rather is a result of the need to sever the subbasal nerve plexus in the anterior stroma, which tends to be regenerate in a less comprehensive manner and significantly slower around the margins of the flap compared to other methods.

Flaps aren't inherently dangerous either (flap detachments are very rare, even more so with modern systems that create essentially a cavity where the flap can rest in), but the difference in healing post OP is a lead cause of heightened dry eye after LASIK. Both PRK and SMILE, due to the way they work, are less likely to suffer from this, but every procedure has trade-offs naturally.

With PRK, the epithelium in the area is removed and has to regrow, a process that takes a few days (to get the initial part done, full regrowth takes far longer but isn't noticeable in general). This regrowth can be both rather painful and also rob you of the "instantly perfect sight"-effect many people desire from their laser eye surgery. As the epithelium does regrow naturally however, it is less likely (both in theory and in medical literature) to lead to dry eye and other side effects in the short and long term, making it the preferred choice by many ophthalmologists when choosing such surgery for themselves.

SMILE, on paper, might be able to offer the best of both worlds, but is severely more expensive than either and there is not a sufficient degree of long term research to make a definitive statement that the side effect amount and severity is comparable to PRK, simply because it is rather new. What research is out there is promising though.

Overall, each option is very well tolerated, leads to major QOL improvements and we need to keep in mind that even the more common side effects one may face with LASIK may not affect everyone and still are comparably small considering other medical fields and their elective procedures.

In this context, I'm very excited to see whether this method might have even fewer short and long term side effects than PRK, but like with SMILE, it may take decades to have a conclusive answer.

Edit: Another thing I missed and which was not covered in the article, is the potential that this new method could be applicable to people who, because of a variety of factors, are not eligible for any ablative eye surgery. I myself was at the upper limit for Trans-PRK in regard to the severity of my Myopia and the thickness (or lack there off) of my Epithelium. In that regard, I see far more potential than just reducing already low side-effect risks further.

Nevermark - 2 days ago

I have keratoconus, which is where a lack of strength in my corneas has resulted in their losing their proper shapes.

I have several focal points in each eye, randomly clustered together. And unfortunately, there is no correlation (or reason for a correlation) between my eyes.

Imagine not being cross-eyed with two focal points, but with well over a baker's dozen. Even if I could line up one pair of points between my eyes, any improvement would be indiscernible in the mess I see.

Because the focal points are clustered close together, their impact is less at a distance (it just feels hard/impossible to properly focus, like looking through very slightly warped glass), but it is devastating up close. For reading.

Without help, I see so many copies of all the letters, randomly and tightly stamped all over each other, I could stare at a short line of text all day and never figure out what it said.

And this after having better than 20-20 vision at all distances, for most of my life.

(Fun fact: if I am in a dark room, and look at one of those tiny power-on LED lights on some media equipment with enough distance that it is basically a point, I can clearly see all my focal points - and also a dimmer curvy, spaghetti crossover mess of focal Beziers between and around them. My corneas are neither convex or concave. They are chaotic. Evil.)

Fortunately, I have hard gas-permeable "scleral" contact lenses. They form a near perfect cornea for me, so when I wear them, my awesome vision and glyphs live once again. "Scleral" refers to the fact that they are wide enough to rest on the whites (sclera) of the eyes, to completely cover and fill out my lame natural corneas.

So I am in pretty good if inconvenient shape.

But I would absolutely love it if this new method allowed my corneas to be reshaped. Any improvement would be a big deal.

(There is surgery where corneas are soaked with a binder, which is fixed with a laser, that strengthens them and stops/slows Keratoconus from getting worse. But it cannot recover what has already been lost.)

stevetron - 3 days ago

I wouldn't trust it, myself. I was laying out a new circuit board design for a client when my eyesight went all wonky. It turns out I had a detached retina. Yhe first repair procedure failed. The second procedure went well. Then I got a cataract in that eye. My retina specialist sent me to a cataract specialist. The cataract specialist told me "I was allergic to laser beams" and didn't recommend cataract surgery. And also to get used to audiobooks. Like I could write program code and design GUI's by listening to audiobooks. For "fun" I read. Sometimes I write books. I put up with a 'weird' double vision and gave up driving a car. Audiobooks indeed.

Tade0 - 3 days ago

Finally some news regarding this research. I first heard about it back in 2019 when there was an ACS panel featuring it:

https://www.youtube.com/live/Dw9D7C8CpM0?si=e-KJ8J2u_oVy4RvM

Originally there was a mention of developing a less invasive method of correcting a deviated septum, but I guess they went with the harder problem first.

In any case I'm up for both, because while my vision is not terrible, it's slowly, but consistently getting worse, so max-twice-a-lifetime interventions like laser eye surgery won't cut it for me.

InMice - 3 days ago

Would anyone know could they use this to fix the glares and halos from lights at night in person's vision, I understand cannot be fixed with any technology now? Including risk of making worse by laser surgery.

I only have wore glasses, i dont care about trying contacts. Its the glare with or without thats pretty bad driving at night in US

gokhan - 3 days ago

If it can reshape cartilage, i can imagine the queue outside of doctor's office for nose jobs.

chronogram - 3 days ago

This seems ideal. The only question I had was whether it's permanent on living cells, "Potentially reversible" at the end makes me think it is.

zenmac - 2 days ago

Interesting article. For myopida, there is also this Ortho-K and a specialized version of it from a Canadian optometrist, where one get a K test and then they make a set of customized lens based on the test, and there are these daily exercise that one needs to do while wearing them the lens. Many testimonies claim that they corrected their vision after 6 months.

PaywallBuster - 3 days ago

> Though the next steps are planned, uncertainties in the team's scientific funding have put them on hold

take my money!

ridgeguy - 2 days ago

Every time I consider LASIK or other procedures that would remove my need for glasses, I recall that in 23 years, my obligate glasses have saved each eye once. Two dead center strikes from disintegrating server cooling fan blades. I'd have lost both eyes.

chpatrick - 3 days ago

I think they'll have to come up with a less scary name for it though.

mkotlikov - 2 days ago

I use ortho k, I exclusively sleep in my contact lenses, take them out when I wake up and enjoy 20/20 vision for 24+ hours. I don't have to sleep in them every night to maintain 20/20, but I do anyways.

They are basically retainer contact lenses that reshape your cornea as you sleep. It's what's described here minus the pH change and electric potential.

scotty79 - 3 days ago

That's great news. I was discouraged of laser correction when I read some research that the layer they cut off and put back on doesn't really fuse back with the rest of the eyeball. The adhesion force is if I remember correctly 8% of the original. I wouldn't want to risk accidentally rubbing off an important chunk of my corona. The other option is just to cut it off completely and shape what's underneath but that heals slower and is also not great because the top layer is not the same as what's below.

I'm reading that flap detachment is very rare. It very well might be. Maybe the eye is vastly over-engineered and 8% is sufficient for most modern humans. But I'm sceptical.

amelius - 3 days ago

As we age, most of us will have to deal with farsightedness. What's the best treatment option nowadays, besides prescription glasses?

jacknews - 3 days ago

This is amazing!

Let's hope it pans out for eyesight, and I'm sure there must be a whole lot of other things this could apply to.

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msk-lywenn - 3 days ago

I always wondered why we don't reshape eyes somewhat like we do for teeth. I guess this is coming. I can't wait to have more news about this as my severe myopia can't be treated by (most?) laser methods.

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gethly - 2 days ago

In the past, people used to fix bad eyesight by walking in nature and constantly focusing on near and distant objects which forces the eye to constantly work and fix itself in some cases. People nowadays sit behind a computer screen and therefore their eyes are quite passive in the range of use and eyesight problems never get fixed naturally.

imzadi - 3 days ago

One thing I am curious about is if the platinum shaping lens would be the same for everyone or is it custom made?

j45 - 3 days ago

The eyewear industry might not like this.

aatd86 - 3 days ago

So, electrochemical ortho-K but better?